Predictors of a metabolically unhealthy obesity
https://doi.org/10.15829/1728-8800-2025-4212
EDN: LIAJXY
Abstract
Over the past 50 years, the number of obese people has increased many times. Despite the excess weight, many patients may be metabolically healthy. But studies show that this condition is an intermediate stage ending with a metabolically unhealthy phenotype, which is associated with an increase in the incidence of cardiovascular events. The concept of metabolically unhealthy obesity is characterized by altered levels of various biomarkers, the significance of which in the context of predicting a metabolically unhealthy phenotype remains to be studied. The review is devoted to the analysis of modern research data on the role of hyperuricemia, gut microbiota and its metabolites, adipocytokines, as well as an assessment of their relationship with a metabolically unhealthy obesity.
About the Authors
Yu. V. Burenkov
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Voronezh
V. I. Shevtsova
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Voronezh
O. N. Krasnorutskaya
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Voronezh
Yu. A. Kotova
Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
Voronezh
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Supplementary files
What is already known about the subject?
- Obesity may not be accompanied by metabolic disorders, which explains the existence of several obesity phenotypes.
- Metabolic healthy obesity in some cases can transform into a metabolically unhealthy phenotype.
What might this study add?
- An increase in the level of uric acid, leptin and a decrease in serum adiponectin show a clear correlation with metabolically unhealthy obesity.
- The study of changes in the composition of gut microbiota and its metabolites in metabolically unhealthy obesity is a promising direction of research.
- The studied biomarkers are associated with an imbalance of pro-inflammatory and anti-inflammatory mechanisms in the body.
Review
For citations:
Burenkov Yu.V., Shevtsova V.I., Krasnorutskaya O.N., Kotova Yu.A. Predictors of a metabolically unhealthy obesity. Cardiovascular Therapy and Prevention. 2025;24(2):4212. (In Russ.) https://doi.org/10.15829/1728-8800-2025-4212. EDN: LIAJXY
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