Evaluation of purine metabolites after coronary artery bypass grafting in overweight and normal-­weight patients

Aim. To study the purine metabolism changes in overweight patients who underwent coronary artery bypass grafting (CABG) in the early postoperative period and during the rehabilitation, compared with that in patients with normal body weight.

Material and methods. This prospective study included 155 patients, including 87 (56%) men and 68 (44%) women, who underwent CABG due to critical coronary artery stenosis. All patients were diagnosed with single-­vessel disease. The age range was 35-65 years. Patients we­re divided into 3 following groups: group 1 (n=85) — overweight pa­tients; group 2 (n=70) — patients with normal body weight; group 3 (con­trol group) — 30 healthy individuals. Changes in purine metabolite le­vels were assessed over time: 1 day after blood flow restoration at the cardiac surgery center, and then at rehabilitation stages 1 (1 to 3 months), 2 (3 to 6 months), and 3 (6 months to 1 year) at the cardiac re­ha­bi­lita­tion center. Statistical analysis was performed using SPSS 27.0 and MedCalc version 22 software. The data are presented as tables and graphs using GraphPad PrismTM (version 7).

Results. In overweight patients after CABG, purine metabolite levels initially decrease, including in rehabilitation stages 1 and 2, and then sharply increase in rehabilitation stage 3.

Conclusion. In overweight patients, the level of purine metabolites in­creases sharply after CABG at rehabilitation stage 3 compared to those at stages 1 and 2, suggesting resumption of the pathological process (ischemia, inflammation).

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