Newly diagnosed patent foramen ovale in an elderly patient: a case report
https://doi.org/10.15829/1728-8800-2025-4260
EDN: MJGIHI
Abstract
Penitent foramen ovale (PFO) is a structural heart abnormality with a frequency in the general population of ~27;3%; which consists of interatrial communication and related syndromes. It is often clinically asymptomatic and can be a diagnostic finding or characterized by thromboembolic events at the onset; most often ischemic stroke; transient ischemic attack; as a result of paradoxical embolism. Today; there is no doubt about the importance of shunting through the PFO in the pathogenesis of paradoxical embolism. However; there is still no unified approach to risk stratification of thromboembolic events in PFO. In addition; there are still discrepancies in determining the optimal treatment strategy for PFO in adults. A personalized approach to each patient with PFO depends on age; hemodynamic significance; shunting direction; clinical performance; and risk of cardioembolic events.
About the Authors
O. V. SoldatovaRussian Federation
Simferopol
I. Ya. Goryanskaya
Russian Federation
Simferopol
References
1. Homma S, Sacco R. Patent foramen ovale and stroke. Circulation. 2005;112:1063-72. doi:10.1161/CIRCULATIONAHA.104.524371.
2. Rybakova MK, Mitkov VV, Baldin DG. Small abnormalities of the heart and an open oval window: myths and reality. Consilium Medicum. 2017;19(5):76-80. (In Russ.)
3. Joaquin B Gonzalez, Fernando D Testai. Advances and Ongoing Controversies in Patent Foramen Ovale Closure and Cryptogenic Stroke. Neurol Clin. 2021;39(1):51-69. doi:10.1016/j.ncl.2020.09.013.
4. Mekhryakov SA, Kulesh AA, Pokalenko EA, et al. The paradoxical embolism phenomenon in patients with embolic cryptogenic stroke. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(1): 13-21. (In Russ.) doi:10.14412/2074-2711-2020-1-13-21.
5. Farjat-Pasos JI, Guedeney P, Houde C, et al. Sex Differences in Patients With Cryptogenic Cerebrovascular Events Undergoing Transcatheter Closure of Patent Foramen Ovale. J Am Heart Assoc. 2023;12(19):e030359. doi:10.1161/JAHA.123.030359.
6. Supranational (International) guidelines for management of the heart structural anomalies. Medical Vestnik of North Caucasus. 2018;13(1.2):272-324. (In Russ.) doi:10.14300/mnnc.2018.13040.
7. Hart RG, Diener HC, Coutts SB, et al. Cryptogenic Stroke/ESUS International Working Group. Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol. 2014;13(4):429-38. doi:10.1016/S1474-4422(13)70310-7.
8. Kent DM, Saver J, Ruthazer R, et al. Risk of Paradoxical Embolism (RoPE)-Estimated Attributable Fraction Correlates With the Benefit of Patent Foramen Ovale Closure: An Analysis of 3 Trials. Stroke. 2020;51(10):3119-23. doi:10.1161/STROKEAHA.120.029350.
9. Low CE, Teo YN, Teo YH, et al. Propensity-score matched analysis of patent foramen ovale closure in real-world study cohort with cryptogenic ischemic stroke. J Stroke Cerebrovasc Dis. 2023;32(12):107407. doi:10.1016/j.jstrokecerebrovasdis.2023.107407.
10. Rudoy AS, Bova AA, Nekhaichik TA. Open oval window and associated clinical conditions. Klin med. 2017;95(7):607-12. (In Russ.) doi:10.18821/0023-2149-2017-95-7-607-612.
11. Kavinsky CJ, Szerlip M, Goldsweig AM, et al. SCAI Guidelines for the Management of Patent Foramen Ovale. J Soc Cardiovasc Angiogr Interv. 2022;1(4):100039. doi:10.1016/j.jscai.2022.100039.
12. Ognerubov DV, Tereshchenko AS, Samko AN, et al. Safety and efficacy of endovascular patent foramen ovale closure: the first results of a Russian multicenter study. Neurology, Neuro¬psychiatry, Psychosomatics. 2020;12(6):26-32. (In Russ.) doi:10.14412/2074-2711-2020-6-26-32.
13. Alperi A, Guedeney P, Horlick E, et al. Transcatheter Closure of Patent Foramen Ovale in Older Patients With Cryptogenic Thromboembolic Events. Circ Cardiovasc Interv. 2022; 15(7):e011652. doi:10.1161/CIRCINTERVENTIONS.121.011652.
Supplementary files
- A case of an elderly patient with a newly diagnosed structural heart abnormality — patent foramen ovale, detected by transesophageal echocardiography is presented.
- The patient was hospitalized for a stable angina and repeatedly examined using transthoracic echocardiography, which did not reveal the abnormality.
- The rationale of patent foramen ovale in a 61-year-old patient and the subsequent patient routing is considered.
Review
For citations:
Soldatova O.V., Goryanskaya I.Ya. Newly diagnosed patent foramen ovale in an elderly patient: a case report. Cardiovascular Therapy and Prevention. 2025;24(3):4260. (In Russ.) https://doi.org/10.15829/1728-8800-2025-4260. EDN: MJGIHI