A COMPARISON OF THE MAIN ANTIHYPERTENSIVE DRUGS FROM THE VIEWPOINT OF AORTIC STIFFNESS MODIFICATION IN ARTERIAL HYPERTENSION
https://doi.org/10.15829/1728-8800-2014-2-76-79
Abstract
A plenty of trials confirm the importance of aortic wall stiffness evaluation during estimation of the cardiovascular risk and the need for novel drugs influencing this parameter. Most of hypotensive medications modify arterial wall siffness by one or another way. So the usage of drug combination might be more effective. Insufficient impact of betaadrenoblockers on central artrial pressure is linked to peripheral vasoconstriction. The drugs within this class having vasodilatory properties significantly reduce central aortic pressure.
About the Authors
E. Yu. Shupenina
Moscow State Medical and Stomatology University n. a. Evdokimov; Moscow, Russia
Russian Federation
Russian Federation
Yu. A. Vasyuk
Moscow State Medical and Stomatology University n. a. Evdokimov; Moscow, Russia
Russian Federation
Russian Federation
A. B. Khadzegova
Moscow State Medical and Stomatology University n. a. Evdokimov; Moscow, Russia
Russian Federation
Russian Federation
S. V. Ivanova
Moscow State Medical and Stomatology University n. a. Evdokimov; Moscow, Russia
Russian Federation
Russian Federation
E. V. Nadina
Moscow State Medical and Stomatology University n. a. Evdokimov; Moscow, Russia
Russian Federation
Russian Federation
A. M. Khuchinaeva
Moscow State Medical and Stomatology University n. a. Evdokimov; Moscow, Russia
Russian Federation
Russian Federation
References
1. Guerin AP, Blacher J, Pannier B, et al. Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation 2001; 103 p. 987–92.
2. Williams B, Lacy PS, Thom SM, et al. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 2006; 113 (9): 1213–25.
3. Roman MJ, Devereux RB, Kizer JR, et al. Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study. Hypertension 2007; 50: 197–203.
4. Wang KL, Cheng HM, Chuang HM, et al. Central or peripheral systolic or pulse pressure: which one best relates to target organs future mortality? J Hypertens 2009; 27: 461–7.
5. Vlachopoulos C, Aznaouridis K, Stefanadis C, et al. Prediction of cardiovascular events and all cause mortality with central haemodynamics: a systematic review and meta-analysis. Eur Heart J 2010; 31: 1865–71.
6. London GM, Blacher J, Pannier B, et al. Arterial wave reflections and survival in endstage renal failure. Hypertension 2001; 38: 434–8.
7. Tropeano Al, Boutouyrie P, Pannier B, et al. Brachial pressure-independent reduction in carotid stiffness after long-term angiotensin-converting enzyme inhibition in diabetic hypertensives. Hypertension 2006; 48: 80–6.
8. Mackenzie IS, McEniery CM, Dhakam Z, et al. Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension. Hypertension 2009; 54 p. 409–13.
9. Tomiyama H, Yoshida M, Yamada J. Arterial-cardiac destiffening following long-term antihypertensive treatment. Am J Hypertens 2011; 24: 1080–6.
10. Kithas PH, Supiano MA. Spironolactone and hydrochlorthiazide decrease vascular stiffness and blood pressure in geriatric hypertension. J Am Geriatric Soc 2010; 58: 1327–32.
11. Palombo C, Malshi E, Morizzo C. Arterial wave reflection during antihypertensive therapy with barnidipine: a 6-month open label study using an integrated cardiovascular ultrasound approach in patients with newly diagnosed hypertension. Clin Ther 2009; 31 (12): 2873–85.
12. Dart AM, Cameron JD, Gatzka CD. Similar effects of treatment on central and brachial blood pressures in older hypertensive subjects in the Second Australian National Blood Pressure Trial. Hypertension 2007; 49: 1242–7.
13. Asmar RG, London GM, O´Rourke ME, et al. Improvement in blood pressure, arterial stiffness and wave reflections with a very low-dose perindopril/indapamide combination in hypertensive patients: a comparison with atenolol. Hypertension 2001; 38 (4): 922–6.
14. Boutouyrier P, Achouba A, Trunet P, et al. Amlodipine-valsartan combination decreases central systolic blood pressure more effectively than the amlodipineatenolol combination: the EXPLOR study. Hypertension 2010; 55 (6): 1314–22.
15. Topouchian J, Asmar R, Sayegh F. Changes in arterial structure and function under trandolapril-verapamil combination in hypertension. Stroke 1999; 30 (5): 1056–64.
16. Matzui Y, Eguchi K, O’Rourke M. Differential effects between a calcium channel blocker and a diuretic when used in combination with angiotensin II receptor blocker on central aortic pressure in hypertensive patients. Hypertension 2009; 54: 716–23.
17. Mahmud A, Feely J, Beta-blockers reduce aortic stiffness in hypertension but nebivolol, not atenolol, reduces wave reflection. Am J Hypertens 2008; 21: 663–7.
18. Shah NK, Smith SM, Nichols WW. Carvedilol reduces aortic wave reflection and improves left ventricular/vascular coupling: a comparison with atenolol (CENTRAL study). J Clin Hypertens 2011; 13 (12): 917–24.
Review
For citations:
Shupenina E.Yu., Vasyuk Yu.A., Khadzegova A.B., Ivanova S.V., Nadina E.V., Khuchinaeva A.M. A COMPARISON OF THE MAIN ANTIHYPERTENSIVE DRUGS FROM THE VIEWPOINT OF AORTIC STIFFNESS MODIFICATION IN ARTERIAL HYPERTENSION. Cardiovascular Therapy and Prevention. 2014;13(2):76-79. (In Russ.) https://doi.org/10.15829/1728-8800-2014-2-76-79
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