THE SPECIFICS OF HYPERTENSION PREVALENCE IN TYUMENSKAYA REGION AND ITS TREATMENT EFFICACY AMONG INHABITANTS OF 25-64 YEAR OLD

Aim. To study prevalence of arterial hypertension (AH), mean values of  systolic  (SBP)  and  diastolic  (DBP) levels  of  blood  pressure, awareness of patients on this, antihypertension drugs (AD) intake and treatment  efficacy among inhabitants of Tyumen Region, age 25-64 year old.

Material and methods. A cohort of Tyumen Region inhabitants, 25-64 y.o.,  investigated  under  the  framework of multicenter  observational study ESSE-RF. Number of participants  — 1762, of those men 34,4% (n=607), women 65,6% (n=1155), mean age 48,9±11,4 y.o.

Results. In Tyumen Region the prevalence of AH was 48,9%, which is 4,9% higher than general  population in ESSE-RF (by 9 regions). The same  high pressure was  found  in general  population  of men  and women, however statistically significantly predominated  in men aged <55 y.o. The prevalence  of AH increased  with age  — from 17,1% in group  25-34  y.o. to 70,6%  in group  55-64  y.o.,  significantly more frequently registered  in rural inhabitants — 58,1% vs 46,8% (р<0,05) and those  with lower educational  level — 57,4% vs 47,9% (p<0,05). The specifics  of Tyumen Region was low level of awareness about having AH. In difference with the general ESSE-RF selection, with this value 73,1%, awareness on their AH in Tyumen Region was 57,6%. Naturally, this value was higher in women — 60,5% vs 50,6% (р=0,03), city inhabitants — 59,3% vs 51,7% (p<0,05) and persons  with middlelevel or higher education  — 58,4% vs 47,9% (p<0,05).  Not high was the portion of those regularly taking AD — 39,5%, of those effectively treated  39,1%.  Women with AH  significantly more  commonly  took AD — 43,9% vs 23,0%, and were doing this more effectively  — 43,2% vs 24,3% (р<0,01). Efficacy of AD was higher among those with higher education  — 44,7% vs 35,9% (р<0,01),  decreased with the age and did not relate  on the type of settlement.  Of the specifics  of Tyumen Region was not high portion of those with AH reached  target values of BP — 15,4% vs 22,7% in general population of ESSE-RF. This value did not have significant differences  depending  on the  age  and  type of settlement, but was significantly higher among women in the age group >35 y.o., citizens, as  rurals. Correlation of effective BP control with educational  level was found only in male population. Among hypertensive males with middle and higher education, BP control was significantly better comparing to AH patients with low educational level.

Conclusion. The results determined  the aims of prevention work with AH taking the specifics of this factor prevalence in Tyumen Region.

1. Lewington S, Clarke R, Qizilbash N, et al. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002; 360, Issue 9349: 1903-13.

2. Ford ES, Ajani UA, Croft JB, et al. Explaining the Decrease in U. S. Deaths from Coronary Disease, 1980-2000. The New England Journal of Medicine 2007; 356; 237, p 2388-98.

3. Boytsov SA, Balanova YuA, Shalnova SA, et al. Arterial hypertension among individuals of 25-64 years old: prevalence, awareness, treatment and control. By the data from ECCD. Cardiovascular Therapy and Prevention 2014; 14 (4): 4-14. Russian (Бойцов С. А., Баланова Ю. А., Шальнова С. А и др. от имени участников исследования ЭССЕ-РФ. Артериальная гипертония среди лиц 25-64 лет: распространенность, осведомленность, лечение и контроль. По материалам исследования ЭССЕ. Кардиоваскулярная терапия и профилактика 2014; 14 (4): 4-14).

4. Kearney P, Whelton M, Reynolds K, et al. Worldwide prevalence of hypertension: a systematic review. J Hypertens 2004; 22: 11-9.

5. Lawes CM, Hoorn SV, Rodgers A. Global burden of blood-pressure-related disease. 2001. Lancet 2008; 371; Issue 9623: 1513-8.

6. Vorobjeva OD, Denisenko MB, Elizarov VV, et al. The Demographic Yearbook of Russia. 2013: Statistical Handbook. Rosstat. M. 2013; 543 p. Russian (Воробьева О. Д., Денисенко М. Б., Елизаров В. В. и др. Демографический ежегодник России, Стат.сб. Росстат. M 2013; 543 c. http://www.gks.ru).

7. Scientific Organizing Committee of the ESSE-RF. Epidemiology of cardiovascular diseases in different regions of Russia (ESSE-RF). The rationale for and design of the study. Preventive Medicine 2013; 6: 25-34. Russian (Научно-организационный комитет проекта ЭССЕ-РФ Эпидемиология сердечно-сосудистых заболеваний в различных регионах России (ЭССЕ-РФ). Обоснование и дизайн исследования. Профилактическая медицина 2013, 6: 25-34).

8. Shalnova SA, Conradi AO, Karpov YuA, et al. Cardiovascular mortality in 12 Russian federation regions — participants of the "Cardiovascular disease epidemiology in Russian regions" study. Russ J Cardiol 2012; 5 (97): 6-11. Russian (Шальнова С. А., Конради А. О., Карпов Ю. А. и др. Анализ смертности от сердечно-сосудистых заболеваний в 12 регионах Российской Федерации, участвующих в исследовании "Эпидемиология сердечно-сосудистых заболеваний в различных регионах России". Российский кардиологический журнал 2012; 5 (97): 6-11).

9. Dorobantu M, Darabont RO, Badila E, et al. Prevalence, Awareness, Treatment, and Control of Hypertension in Romania: Results of the SEPHAR Study. Int. J Hypertens 2010; Article ID 970694, 6 pages, doi:10,4061/2010/970694.

10. Grujic V, Dragnic N, Kvrgic S. Epidemiology of Hypertension in Serbia: Results of a National Survey. J Epidemiol 2012; 22 (3): 261-6.

11. Meng XJ, Dong GH, Wang D, et al. Prevalence, awareness, treatment, control, and risk factors associated with hypertension in urban adults from 33 communities of China: the CHPSNE study. J Hypertens 2011; 29 Issue 7: 1303-10.

12. Joffres M, Falaschetti E, Gillespie C. Hypertension prevalence, awareness, treatment and control in national surveys from England, the USA and Canada, and correlation with stroke and ischaemic heart disease mortality: a cross-sectional study. BMJ Open 2013; 3: e003423. doi:10.1136/bmjopen-2013-003423

13. Chow СК, Teo KK, Rangarajan S, et al. Prevalence, Awareness, Treatment, and Control of Hypertension in Rural and Urban Communities in High-, Middle-, and LowIncome Countries. JAMA 2013; 310 (9): 959-68.

14. Gu Q, Burt VL, Dillon CF, et al. Trends in Antihypertensive Medication Use and Blood Pressure Control Among United States adults With Hypertension: The National Health and Nutrition Examination Survey, 2001 to 2010. Circulation 2012; 126: 2105-14.

15. Llisterri JL, Rodriguez-Roca GC, Escobar C, et al. Treatment and blood pressure control in Spain during 2002-2010. J Hypertens 2012; 30, Issue 12: 2425-31.