COGNITION DISORDERS IN HYPERTENSIVE PATIENTS OF OLDER AGE AND SENILE
https://doi.org/10.15829/1728-8800-2017-3-34-38
Abstract
Aim. To assess cognitive status of the older age patients with arterial hypertension, in outpatient setting.
Material and methods. Totally, 356 patients included, age 74,9±6,1 y., 80,4% females. For cognition assessment before and after the treatment, neuropsychological test was done, with MMSE — short scale of psychic status assessment, drawing test; literal and categoric associations test.
Results. In the group <80 y.o. the prominence of MMSE disorders correlated with blood pressure values (BP): for systolic BP (r=-0,22, р=0,0003), for diastolic BP (r=-0,13, p=0,03), i.e. in higher BP patients there were lower points in cognition scale by Spearman correlation. In the group ≥80 y. both correlations were non-significant, for systolic BP (r=-0,05, p=0,64), and for diastolic BP (r=-0,13, р=0,25).
Conclusion. In older age and senile patients with arterial hypertension there should be differential approach to BP management according to the age and cognition disorders, complex approach to treatment in these patients might prevent further worsening of cognitive decline.
About the Authors
N. V. SharashkinaRussian Federation
Moscow, +7 (903) 244-27-50
V. S. Ostapenko
Russian Federation
Moscow
О. N. Tkacheva
Russian Federation
Moscow
N. К. Runikhina
Russian Federation
Moscow
Yu. V. Kotovskaya
Russian Federation
Moscow
E. A. Mkhitarian
Russian Federation
Moscow
S. N. Lysenkov
Russian Federation
Moscow
References
1. Forette F, Seux M, Staussen J. Systolic Hypertension in Europe Investigators. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med 2002; 14 Vol. 162(18): 2046-52.
2. Belleli G, Blanchetti A, Trabucchi M. Blood pressure and cognitive impairment in the elderly. Curr Hypertens Rev 2006; 2(1): 1-9.
3. Kearney-schwartz A, Кossignol P, Bracard S, et al. Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke 2009; 40: 1229-36.
4. Rabkin S, Jarvie G. Comparison of vascular stiffness in vascular dementia, Alzheimer dementia and cognitive impairment. Blood Press 2011; 20(5): 274-83.
5. Larrieu S, Letenneur L, Porgogozo J. Incidence and outcome of mild cognitive impairment in a population-based prospective cohort. Neurology 2002; 59: 1594-9.
6. Sojkova J, Beason-Held LL, Metter EJ. Intima-Media Thickness and Regional Cerebral Blood Flow in Older Adults. Stroke 2010; 41: 273-9.
7. Grady CL. Functional brain imaging and age-related changes in cognition. Biological Psychology 2000; 54: 259-81.
8. Verhaaren B, Vernooij M, de Boer R, et al. High blood pressure and cerebral white matter lesion progression in the general population. Hypertension 2013; 61(6): 1354-9.
9. Singh-Manoux A, Marmot M. High blood pressure was associated with cognitive function in middle–age in the Whitehall II study. J Clin Epidemiol 2005; 58: 1308-15.
10. Tzourio C, Dufouil C, Ducimetiere P, Alperovitch A. Cognitive decline in individuals with high blood pressure: a longitudinal study in the elderly. EVA Group. Neurology 1999; 53: 1948-52.
11. Petrovitch H, White LR, Ross GW, et al. Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study. Neurology 2001; 24; 57(2): 226-34.
12. Jakobsson E, Gaston-Johansson F, Ohldn J, Bergh I. Clinical problems at the end of life in a Swedish population, including the role of advancing age and physical and cognitive function. Scand J Public Health 2008; 36(2): 177-82.
13. Kilander L, Nyman H, Boberg M, et al. Hypertension isrelated to cognitive impairment: a 20-year follow-up of 999 men. Hypertension 1998; 31: 780-6.
14. Ronnemaa E, Zethelius B, Lannfelt L, Kilander L. Vascular risk factors and dementia: 40-year follow-up of a population-based cohort. Dement Geriatr Cogn Disord 2011; 31(6): 460-6.
15. Sabayan B, Oleksik A, Maier A, et al. High blood pressure and resilience to physical and cognitive decline in the oldest old: the Leiden 85-plus Study. J Am Geriatr Soc 2012; 60: 2014-9.
16. Wimo A, Winblad B, Aguero-Torres H, et al. The magnitude of dementia occurrence in the world. Alzheimer Dis Assoc Disord 2003; 17(2): 63-7.
Review
For citations:
Sharashkina N.V., Ostapenko V.S., Tkacheva О.N., Runikhina N.К., Kotovskaya Yu.V., Mkhitarian E.A., Lysenkov S.N. COGNITION DISORDERS IN HYPERTENSIVE PATIENTS OF OLDER AGE AND SENILE. Cardiovascular Therapy and Prevention. 2017;16(3):34-38. (In Russ.) https://doi.org/10.15829/1728-8800-2017-3-34-38