DELETIONAL POLYMORPHISM OF GLUTATHIONE TRANSFERASE T1 AND M1 GENES IN PATIENTS WITH MYOCARDIAL INFARCTION AND METABOLIC SYNDROME
https://doi.org/10.15829/1728-8800-2014-3-47-52
Abstract
Aim. To study associations of deletional polymorphism of genes GSTM1 and GSTT1 with myocardial infarction (MI) development on the background of metabolic syndrome (MS).
Material and methods. Totally 86 patients with STEMI were included (from those 45 had signs of MS) and 30 healthy persons as control. By polymerase chain reaction the data on deletional polymorphism was obtained on the genes coding glutathiontransferase GSTM1 and GSTT1 in both groups.
Results. The significant increase of prevalence of genotype GSTT10/0 is ascertained in patients with MI and without MS; presence of the “null” genotype increases relative risk of infarction in both patients with and without MS. In the first group (without MS) presence of genotype GSTT10/0 leads to increase of MI risk irrespective of smoking status, though in MS patients — only in those who smokes.
Conclusion. Diagnostic of homozygous deletional mutation GSTT1 can be used for individual prognosis of MI risk in patients with MI risk factors — smoking and MS.
About the Authors
V. A. Nevzorova
SBEI HPE “Pacific Ocean State Medical University” of the Ministry of Health
Russian Federation
Russian Federation
E. A. Panchenko
SBEI HPE “Pacific Ocean State Medical University” of the Ministry of Health
Russian Federation
Russian Federation
M. P. Isaeva
FSBSI “Pacific Ocean Institute for Bio-organic Chemistry n. a. Elyakov G. B.” of RAS. Vladivostok, Russia
Russian Federation
Russian Federation
References
1. Martin NJ, Collier AC, Bowen LD, et al. Polymorphisms in the NQO1, GSTT and GSTM genes are associated with coronary heart disease and biomarkers of oxidative stress. Mutat Res 2009; 674: 93–100.
2. Nevzorova VA, Tilik TV, Panchenko EA, et al. Polymorphism of glutathione transferase genes in case of chronic obstructive lung disease assotiated with ischemic heart disease. Tihookeanskij medicinskij zhurnal 2010; 1: 13–5. Russian (Невзорова В. А., Тилик Т. В., Панченко Е. А. и др. Полиморфизм генов глютатионтрансфераз при хронической обструктивной болезни легких, ассоциированной с ишемической болезнью сердца. Тихоокеанский медицинский журнал 2010; 1: 13–5).
3. Hrunin AV, Hohrin DV, Limborskaja SA. Genetic polymorphisms of glutathione S-transferases genes in populations of European part of Russia. Genetika 2008; 44 (10): 1429–34. Russian (Хрунин А. В., Хохрин Д. В., Лимборская С. А. Полиморфизм генов глутатион-S — трансфераз в популяциях русского населения европейской части России. Генетика 2008; 44 (10): 1429–34).
4. Norskov MS, Frikke-Schmidt R, Loft S, et al. Copy number variation in glutathione S-transferases M1 and T1 and ischemic vascular disease: four studies and metaanalysis. Circ Cardio Genetics 2011; 4: 418–28.
5. Wang J, Zou L, Huang S, et al. Genetic polymorphisms of glutathione S-transferase genes GSTM1, GSTT1 and risk of coronary heart disease. Mutagenesis 2010; 25 (4): 365–9.
6. Du Y, Wang H, Fu X, et al. GSTT1 null genotype contributes to coronary heart disease risk: a meta-analysis. Mol Biol Reports 2012; 39 (9): 8571–9.
7. Manfredi S, Federici C, Picano, et al. GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smokingrelated coronary artery disease: a caseonly study. Mutat Res 2007; 621: 106–12.
8. Wang LS, Tang JJ, Tang NP, et al. Association of GSTM1 and GSTT1 gene polymorphisms with coronary artery disease in relation to tobacco smoking. Clin Chem Lab Med 2008; 46: 1720–5.
Review
For citations:
Nevzorova V.A., Panchenko E.A., Isaeva M.P. DELETIONAL POLYMORPHISM OF GLUTATHIONE TRANSFERASE T1 AND M1 GENES IN PATIENTS WITH MYOCARDIAL INFARCTION AND METABOLIC SYNDROME. Cardiovascular Therapy and Prevention. 2014;13(3):47-52. (In Russ.) https://doi.org/10.15829/1728-8800-2014-3-47-52
Views:
801
Email this article 
