Васкулярные ростовые факторы в патогенезе гипертензивных состояний
Аннотация
Обобщение и анализ информации о роли нейротрофических и ростовых факторов в формировании сосудистой патологии, артериальной гипертонии (АГ) и органных поражений (ОП) позволяет определить новые позиции терапевтической стратегии. Становится все более очевидным, что помимо систем пептидных регуляторов (ангиотензин II, эндотелин-1, атриальные натрийуретические факторы), катехоламинов и др. в патогенезе кардиоваскулярных расстройств принимают участие полипептидные ростовые и нейротрофические факторы, встроенные в общую систему химической регуляции. Они выполняют функцию регуляторов нормальных и дисбалансированных процессов и непосредственно причастны к триаде «окислительные стресс – воспаление – эндотелиальная дисфункция», служащей основой развития АГ и ОП. Среди этих факторов первостепенный интерес представляют: Эндотелиальный фактор роста сосудов, Инсулиноподобные факторы роста, Тромбоцитарный ростовой фактор, Трансформирующие ростовые факторы, Фактор роста фибробластов, Фактор некроза опухоли. Структурные и функциональные особенности этих соединений и их значимость в качестве возможных посредников и/или предикторов и мишеней патологических процессов в сосудистой стенке представлены в настоящей статье.
Об авторе
О. А. Гомазков
НИИ биомедицинской химии им. В.Н. Ореховича РАМН, Москва
Россия
Тел.: (095) 247-30-29
Россия
Тел.: (095) 247-30-29
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Рецензия
Для цитирования:
Гомазков О.А. Васкулярные ростовые факторы в патогенезе гипертензивных состояний. Кардиоваскулярная терапия и профилактика. 2005;4(3, ч.I):93-103.
For citation:
Gomazkov O.A. Vascular growth factors in hypertensive state pathogenesis. Cardiovascular Therapy and Prevention. 2005;4(3, ч.I):93-103. (In Russ.)
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