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Кардиоваскулярная терапия и профилактика

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Гипертрофия левого желудочка: роль ренин-ангиотензиновой системы

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Аннотация

В обзоре представлены современные взгляды на механизмы формирования гипертрофии миокарда, где ключевая роль принадлежит активации ренин-ангиотензиновой системы (РАС) и гемодинамической перегрузке; проанализированы основные структурные и функциональные нарушения, имеющие место при гипертрофии и лежащие в основе ее клинических проявлений: диастолическая дисфункция, фиброз миокарда; изложены основные пути медикаментозной коррекции гипертрофии, прежде всего, с помощью блокаторов РАС.

Об авторах

Ф. Т. Агеев
Институт клинической кардиологии им. А.Л. Мясникова ФГУ «РКНПК Росмедтехнологии», г. Москва
Россия


А. Г. Овчинников
Институт клинической кардиологии им. А.Л. Мясникова ФГУ «РКНПК Росмедтехнологии», г. Москва
Россия


В. М. Сербул
Институт клинической кардиологии им. А.Л. Мясникова ФГУ «РКНПК Росмедтехнологии», г. Москва
Россия


Ю. Н. Беленков
Институт клинической кардиологии им. А.Л. Мясникова ФГУ «РКНПК Росмедтехнологии», г. Москва
Россия


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Для цитирования:


Агеев Ф.Т., Овчинников А.Г., Сербул В.М., Беленков Ю.Н. Гипертрофия левого желудочка: роль ренин-ангиотензиновой системы. Кардиоваскулярная терапия и профилактика. 2008;7(2):98-108.

For citation:


Ageev F.T., Ovchinnikov A.G., Serbul V.M., Belenkov Y.N. Left ventricular hypertrophy: renin4angiotensin system role. Cardiovascular Therapy and Prevention. 2008;7(2):98-108. (In Russ.)

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