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Кардиоваскулярная терапия и профилактика

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Патофизиологические механизмы и генетические маркеры рестеноза после чрескожных коронарных вмешательств

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Аннотация

Рестенозирование коронарных артерий (КА) остается главным ограничением эффективности чрескожной транслюминальной коронарной ангиопластики (ЧТКА) и коронарного стентирования (КС). Цель обзора – рассмотреть механизмы патогенеза рестенозирования КА после ЧТКА и КС; проанализировать различные полиморфизмы кандидатных генов, которые могут быть вовлечены в патогенез развития рестеноза после баллонной ангиопластики (БАП) и рестеноза в стенте, как потенциальные генетические маркеры развития рестеноза после ЧТКА и КС.

Патофизиологические механизмы, генетический базис развития рестеноза в стенте и после БАП без стентирования различаются. Существуют гены, которые могут быть использованы как генетические маркеры риска развития рестеноза в стенте. С другой стороны, есть гены, которые служат генетическими маркерами риска развития рестеноза после ЧТКА. Генетическое тестирование перед выполнением ЧТКА, в ближайшем будущем позволит определять пациентов с высоким риском развития рестеноза, что вместе с разработкой новых фармакологических подходов будет способствовать снижению частоты рестенозирования КА после БАП и КС.

Об авторах

Ю. А. Шувалова
ФГУ «Российский кардиологический научно-производственный комплекс» Росздрава, Москва
Россия
Тел.: (495)414-67-98
Факс: (495)414-67-97


А. Н. Мешков
ФГУ «Российский кардиологический научно-производственный комплекс» Росздрава, Москва
Россия
Тел.: (495)414-67-98
Факс: (495)414-67-97


А. И. Каминный
ФГУ «Российский кардиологический научно-производственный комплекс» Росздрава, Москва
Россия
Тел.: (495)414-67-98
Факс: (495)414-67-97


Г. Ф. Пиксина
ФГУ «Российский кардиологический научно-производственный комплекс» Росздрава, Москва
Россия
Тел.: (495)414-67-98
Факс: (495)414-67-97


В. В. Кухарчук
ФГУ «Российский кардиологический научно-производственный комплекс» Росздрава, Москва
Россия
Тел.: (495)414-67-98
Факс: (495)414-67-97


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Для цитирования:


Шувалова Ю.А., Мешков А.Н., Каминный А.И., Пиксина Г.Ф., Кухарчук В.В. Патофизиологические механизмы и генетические маркеры рестеноза после чрескожных коронарных вмешательств. Кардиоваскулярная терапия и профилактика. 2007;6(5):107-114.

For citation:


Shuvalova Y.A., Meshkov A.N., Kaminny A.I., Piksina G.F., Kukharchuk V.V. Restenosis pathophysiological mechanisms and genetic markers after percutaneous coronary interventions. Cardiovascular Therapy and Prevention. 2007;6(5):107-114. (In Russ.)

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