Inflammation markers in atherosclerosis development
Abstract
Aim. To study different inflammation markers at various stages of atherosclerosis progression.
Material and methods. In 174 21-70-year-old people, brachial artery ultrasound (Aloka 5000) was performed to visualize atherosclerotic plaques and assess intima-media thickness (IMT). Immuno-enzyme analysis was used to measure plasma levels of C-reactive protein, CRP (SeroELISA test system, Diagnostic Systems Laboratories, USA), and cytokines — tumor necrosis factor alpha (THF-alpha), interleukins 1, 4 and 8 (IL-1, 2, and 8) (Russian test systems, Cytokine company, St. Petersburg).
Results. The levels of CRP, IL-1, IL-8 and TNF-alpha were dependent on atherosclerotic process stage and IMT CRP levels typical for systemic inflammatory reaction were observed in individuals with subclinical atherosclerosis and patients with post-infarction cardiosclerosis.
Conclusion. There was an association between IMT and latent inflammation activity. Qualitative changes in inflammation intensity were observed even at early stages of atherosclerosis development.
About the Authors
A. P. Shavrin
Academician E.A. Vagner Perm State Medical Academy
Russian Federation
Russian Federation
Ya. B. Khovaeva
Academician E.A. Vagner Perm State Medical Academy
Russian Federation
Russian Federation
V. A. Chereshnev
Academician E.A. Vagner Perm State Medical Academy
Russian Federation
Russian Federation
B. V. Golovskoy
Academician E.A. Vagner Perm State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Shavrin A.P., Khovaeva Ya.B., Chereshnev V.A., Golovskoy B.V. Inflammation markers in atherosclerosis development. Cardiovascular Therapy and Prevention. 2009;8(3):13-15. (In Russ.)
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