Inflammation role in atrial fibrillation pathogenesis
Abstract
High prevalence of atrial fibrillation (AF) and low effectiveness of antiarrhythmic therapy are the reasons for searching a new therapeutic strategy focused on this arrhythmia. Recent studies have demonstrated the link between anatomical atrial structure changes and pro-inflammatory cytokine levels, that led to a new direction in AF pathogenesis investigation. Whether AF paroxysm is primary, or on the contrary, inflammation provokes AF, is still unknown. Inflammation might be not the only cause of atrial arrhythmogenicity but it plays an important role in myocardial predisposition for AF paroxysm. Results of multi-center studies have shown that early administration of ACE inhibitors, angiotensin receptor antagonists, and statins in cardiac patients significantly reduces AF risk, and could be a promising therapeutic strategy.
About the Authors
A. I. TarzimanovaRussian Federation
I. G. Fomina
Russian Federation
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Review
For citations:
Tarzimanova A.I., Fomina I.G. Inflammation role in atrial fibrillation pathogenesis. Cardiovascular Therapy and Prevention. 2006;5(7):91-94. (In Russ.)