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Кардиоваскулярная терапия и профилактика

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Фармакологическая регуляция обмена энергетических субстратов в кардиомиоцитах при патологических состояниях, связанных с ишемией

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Аннотация

Представлен анализ результатов основных исследований, посвященных изучению энергетического метаболизма в кардиомиоцитах (КМЦ) при физиологическом состоянии и ишемии. Особое внимание уделено механизмам регуляции и взаимосвязи между окислением главных энергетических субстратов, а также химическим соединениям и фармакологическим агентам, действующим на ключевые звенья энергетического обмена в условиях ишемии. Лекарственные препараты, которые частично тормозят окисление жирных кислот (ЖК) в миокарде при ишемии, оказывают цитопротективное действие. Важным с точки зрения безопасности их применения в клинических условиях является способность предупреждать аккумуляцию и пагубное воздействие на КМЦ ЖК и их продуктов.

Об авторах

Е. И. Асташкин
Московская медицинская академия им. И.М.Сеченова. Москва
Россия


М. Г. Глезер
Московская медицинская академия им. И.М.Сеченова. Москва
Россия


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Для цитирования:


Асташкин Е.И., Глезер М.Г. Фармакологическая регуляция обмена энергетических субстратов в кардиомиоцитах при патологических состояниях, связанных с ишемией. Кардиоваскулярная терапия и профилактика. 2006;5(7):112-123.

For citation:


Astashkin E.I., Glezer M.G. Pharmaceutical regulation of cardiomyocyte energetic substrate metabolism in ischemia8associated pathology. Cardiovascular Therapy and Prevention. 2006;5(7):112-123. (In Russ.)

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