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Кардиоваскулярная терапия и профилактика

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Клиническое значение кардиопротективных и васкулопротективных эффектов ингибиторов ангиотензин-превращающего фермента при инфаркте миокарда: зофеноприл

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Аннотация

Ингибиторы ангиотензин-превращающего фермента - средства с доказанной способностью улучшать прогноз жизни, заняли прочное место влечении больных, перенесших инфаркт миокарда (ИМ). При ИМ они предотвращают дезадаптивное ремоделирование сердца и сосудов. Выраженность их кардиопротективного и васкулопротективного действий зависит от степени влияния на тканевую ренин-ангиотензин-альдостероновую систему. В рамках крупномасштабного проекта SMILE с использованием зофеноприла, обладающего высокой антиокислительной активностью и пенетрантностью в ткани миокарда и сосудов, доказаны целесообразность и безопасность раннего назначения препарата у гемодинамически стабильных больных передним ИМ без тромболитической терапии, независимо от их возраста, глубины поражения миокарда, наличия или отсутствия артериальной гипертонии и сердечной недостаточности. Получено убедительное клиническое подтверждение способности зофеноприла оказывать антиишемическое действие (один из ключевых механизмов кардиопротекции) независимо от его антигипертензивных эффектов.

Об авторе

Г. К. Киякбаев
Российский университет дружбы народов, г. Москва
Россия


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Для цитирования:


Киякбаев Г.К. Клиническое значение кардиопротективных и васкулопротективных эффектов ингибиторов ангиотензин-превращающего фермента при инфаркте миокарда: зофеноприл. Кардиоваскулярная терапия и профилактика. 2008;7(7):119-127.

For citation:


Кiyakbaev G.K. Clinical role of cardioprotective and vasculoprotective effects of АСЕ inhibitors in myocardial infarction: zofenopril. Cardiovascular Therapy and Prevention. 2008;7(7):119-127. (In Russ.)

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