Толщина комплекса интима-медиа сонных артерии и С-реактивный белок у пациентов с абдоминальным ожирением

Цель. Оценить выраженность атеросклероза методом дуплексного сканирования общих сонных артерий (ОСА) и уровни С-реактивного белка (СРБ) у больных с абдоминальным ожирением (АО) в возрасте 30-55 лет.

Материал и методы. В исследование были включены 203 пациента (средний возраст 45,9+0,5 лет). Из них 152 женщины (средний возраст 45,9+0,8 лет) и 51 мужчина (средний возраст 44,4+1,5 лет) с АО — окружность талии (ОТ) > 80 см у женщин и > 94 см у мужчин. 36,5% пациентов имели избыточную массу тела — индекс массы тела (ИМТ) 28,0+0,2 кг/м², а 63,5% — ожирение (ИМТ 35,1+0,5 кг/м²). Всем пациентам было проведено ультразвуковое дуплексное сканирование (УЗДС) СА. Содержание СРБ определяли количественным турбидиметрическим методом.

Результаты. Для больных с АО характерно раннее развитие атеросклероза СА и повышение уровня СРБ. Атеросклеротические бляшки в ОСА и/или внутренней СА были обнаружены у 39,8% пациентов. Установлена связь между толщиной комплекса интима-медиа (КИМ) ОСА и ОТ а также уровнем инсулина. Выявлена положительная связь между содержанием СРБ и толщиной КИМ, СРБ и уровнем инсулина, СРБ и ОТ СРБ и ИМТ, и отрицательная связь СРБ с концентрацией холестерина липопротеидов высокой плотности.

Заключение. Пациентам с АО > 30 лет рекомендовано выполнение УЗДС ОСА для выявления ранних признаков атеросклероза.

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