Preview

Cardiovascular Therapy and Prevention

Advanced search

Individual dynamics of heart rate variability in treated cardiac patients

Abstract

Aim. To identify the best markers of heart rate variability (HRV) dynamic in treated cardiac patients.

Material and methods. In total, 145 pairs of 24-hour HRV measurements were selected from the treated patients with arterial hypertension, coronary heart disease, and hypercholesterolemia. The analysis included the most widely used HRV parameters, such as SDNN, SDNN index, r-MSSD, triangular index, LF (low-frequency spectre of HRV), HF (high-frequency spectre of HRV), and total power (TP) of HRV spectre. All parameters were assessed throughout 24 hours, during day-time activity and night-time sleep. HRV parameters were regarded as being changed if the difference between two subsequent measurements was over 5%.

Results. The same direction of changes in all HRV parameters during 24 hours, day-time and night-time was observed only in 8 cases (7,8%). Spearman’s correlation analysis demonstrated a strong correlation (r>0,6) between SDNN index24, r-MSSD24, ОМ24 and changes in other HRV parameters. Unidirectional changes for SDNN index24, r-MSSD24 and ОМ24 were observed in 68,9% of the cases; for SDNN index24 and ОМ24 — in 87,4%; for SDNN index24 and r-MSSD24 — in 71,8%; and for r-MSSD24 and ОМ24 — in 81,5%.

Conclusion. In assessing HRV dynamics, SDNNindex24 was the most informative parameter, since its dynamics coincided with the temporal and spectral HRV parameter dynamics in 71%. For r-MSSD24, this percentage reached 67%, and for ОМ24 — 70%.

About the Author

E. Ya. Parnes
Moscow State Medico-Stomatological University
Russian Federation


References

1. Priory SG, Aliot E, Blomstorm-Lundqvist C, et al. Task Force on sudden cardiac death of the European Society of cardiology. Eur Heart J 2001; 22: 1374-450.

2. Парнес Е.Я. Методологические особенности использования спектральных показателей ВСР в оценке состояния больного ИБС. Седьмая научно-практическая конферен¬ция. Диагностика и лечение нарушений регуляции сердечно-сосудистой системы. Москва 2005; 98-106.

3. Heart rate variability. Standarts of measurement, physiological interpretation and clinic use”. Task force of the Europen Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J 1996; 17: 354-81.

4. Malik M, Bigger J, Camm A, et al. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 1996; 93: 1043-65.

5. Balligand JL, Kobzik L, Han X, et al. Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J Biol Chem 1995; 270: 14582-5.

6. Elvan A, Rubart M, Zipes D. NO modulates autonomic effects on sinus discharge rate and AV nodal conduction in open-chest dogs. Am J Physiol 1997; 272: H263-71.

7. Han X, Kobzik L, Severson D, Shimoni Y Characteristics of nitric oxide-mediated cholinergic modulation of calcium current in rabbit sino-atrial node. J Physiology 1998; 509(3): 741-54.

8. Takimoto Y, Aoyama T, Tanaka K, et al. Augmented expression of neuronal nitric oxide synthase in the atria parasympatically decreases heart rate during acute myocardial infarction in rats. Circulation 2002; 105: 490-6.

9. Ursell PC, Mayes M. Anatomic distribution of nitric oxide synthase in the heart. Int J Cardiol 1995; 50: 217-23.

10. Омельяненко М.Г., Краснова Л.Г., Полятыкина Т.С. и др. Роль эндотелиальной дисфункции и метаболического синдрома в патогенезе ранней ишемической болезни сер¬дца у женщин Кардиоваск тер профил 2002; 1: 47-52.

11. Kinlay S, Ganz P. Role of endothelial dysfunction in coronary artery disease and implications for therapy. Am J Cardiol 1997; 80: 11I-6.

12. Quyyumi AA, Dakak N, Mulcahy D, et al. 3rd. Nitric oxide activity in the atherosclerotic human coronary circulation. JACC 1997; 29(2): 308-17.

13. Massion PB, Feron O, Dessy C, Balligand J-L. Nitric Oxide and Cardiac Function. Circ Res 2003; 93: 388.

14. Wennerblom B, Lurje L, Tygesen H, et al. Patients with uncomplicated coronary disease have reduced heart rate variability mainly affecting vagal tone. Heart 2000; 83(3): 290-4.

15. Manfrini O, Pizzi C, Trere D, et al. Parasympathetic failure and risk of subsequent coronary events in unstable angina and non- ST-segment elevation myocardial infarction. Eur Heart J 2003; 24(17): 1560-6.

16. Singer DH, Martin GJ, Magid N, et al. Low heart rate variability and sudden cardiac death. J Electrocardiol 1988; 21 Suppl: S46- 55.

17. Парнес Е.Я. Клиническое значение вариабельности сер¬дечного ритма у больных ишемической болезнью сердца. Автореф дисс докт мед наук. Москва 2007.

18. Ваулин Н.А., Грацианский Н.А., Явелов И.С., Аверков О.В. Нестабильная стенокардия. Влияние правастатина на результаты суточного мониторирования ЭКГ и велоэр¬гометрических тестов. Кардиология 2001; 41(5): 4-8.

19. Pelat М, Dessy С, Massion Р, et al. Rosuvastatin Decreases Caveolin-1 and Improves Nitric Oxide-Dependent Heart Rate and Blood Pressure Variability in Apolipoprotein E-/- Mice In Vivo. Circulation 2003; 107(19): 2480-6.

20. Pliquett RU, Cornish KG, Zucker IH. Statin therapy restores sympathovagal balance in experimental heart failure. J Appl Physiol 2003; 95(2): 700-4.


Review

For citations:


Parnes E.Ya. Individual dynamics of heart rate variability in treated cardiac patients. Cardiovascular Therapy and Prevention. 2009;8(5):57-61. (In Russ.)

Views: 534


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)