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Кардиоваскулярная терапия и профилактика

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Биохимическим, структурный и клиническим анализ плейотропных эффектов статинов

Аннотация

Предпринята попытка на основании анализа результатов клинических и экспериментальных исследова­ний выстроить доказательную линию плейотропного действия статинов, которое подразумевает включение нескольких механизмов реализации их активности. Понятие плейотропности предполагает: (а) влияние препарата на несколько мишеней, запускающее различные биохимические процессы в организме; (б) дивергенцию биохимических и патофизиологических процессов, исходящих от основной (единственной) мишени. Описаны патохимические механизмы эффектов статинов, как ингибиторов фермента редуктазы коэнзима А, с обоснованием того, что терапевтическое и побочное действия статинов не обязательно связаны с их влиянием на метаболизм липидов и снижением уровня холестерина.

Об авторах

А. Н. Бритов
Государственный научно-исследовательский центр профилактической медицины Росмедтехнологии
Россия

Ведущий научный сотрудник отдела разработки клинических методов вторичной профилактики.

Москва



О. А. Гомазков
НИИ биологической и медицинской химии им. В.Н.Ореховича РАМН
Россия

Главный научный сотрудник.

Москва, тел.: (495) 938-07-36



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Рецензия

Для цитирования:


Бритов А.Н., Гомазков О.А. Биохимическим, структурный и клиническим анализ плейотропных эффектов статинов. Кардиоваскулярная терапия и профилактика. 2009;8(5):92-102.

For citation:


Britov A.N., Gomazkov O.A. Biochemical, structural and clinical analysis of statins’ pleiotropic effects. Cardiovascular Therapy and Prevention. 2009;8(5):92-102. (In Russ.)

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