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Кардиоваскулярная терапия и профилактика

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Старение сосудов: основные признаки и механизмы

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Аннотация

Обсуждаются основные морфологические и функциональные изменения сосудов в процессе старения, механизмы развития, возможности их коррекции.

Об авторах

И. Д. Стражеско
ФГБУ Государственный научно-исследовательский центр профилактической медицины Минздравсоцразвития России, Москва
Россия

(контактное лицо) – в.н.с. отдела комплексного снижения риска неинфекционных заболеваний

Тел.: (985) 210-73-27



Д. У. Акашева
ФГБУ Государственный научно-исследовательский центр профилактической медицины Минздравсоцразвития России, Москва
Россия

с.н.с. отдела

Тел.: (985) 210-73-27



Е. Н. Дудинская
ФГБУ Государственный научно-исследовательский центр профилактической медицины Минздравсоцразвития России, Москва
Россия

с.н.с. отдела

Тел.: (985) 210-73-27



О. Н. Ткачева
ФГБУ Государственный научно-исследовательский центр профилактической медицины Минздравсоцразвития России, Москва
Россия

руководитель отдела

Тел.: (985) 210-73-27



Список литературы

1. Lim MA, Townsend RR. Arterial compliance in the elderly: its effect on blood pressure measurement and cardiovascular outcomes. Clin Geriatr Med 2009; 25: 191-205.

2. US Census Bureau. 2008 National populations projections. http://www.census.gov/population/www/projections/tablesandcharts.html.Accessed September 20, 2010.

3. Virmani R, Avolio AP, Mergner WJ, et al. Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis: comparison between occidental and Chinese communities. Am J Pathol 1991; 139: 1119-29.

4. Miles EA, Rees D, Banerjee T, et al. Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations. Atherosclerosis 2008; 196: 298-305.

5. Herrmann J, Lerman A. The Endothelium – the Cardiovascular Health Barometer. Herz 2008; 33: 343-53.

6. Wang M, Lakatta EG. Central arterial aging: humans to molecules. In: Safar M, editor. Handbook of hypertension: arterial stiffness in hypertension. Amsterdam: Elsevier 2006; 137-60.

7. Hamel E. Perivascular nerves and the regulation of cerebrovascular tone. J Appl Physiol 2006; 100: 1059-64.

8. Saenz de Tejada I, Angulo J, Cellek S, et al. Pathophysiology of erectile dysfunction. J Sex Med 2005; 2: 26-39.

9. Provis JM, Penfold PL, Cornish EE, et al. Anatomy and development of the macula: specialisation and the vulnerability to macular degeneration. Clin Exp Optom 2005; 88: 269-81.

10. Izikki M, Fadel E, Humbert M, et al. Role for dysregulated endotheliumderived FGF2 signaling in progression of pulmonary hypertension. Rev Mal Respir 2008; 25: 1192.

11. McCarron RM, Chen Y, Tomori T, et al. Endothelial-mediated regulation of cerebral microcirculation. J Physiol Pharmacol 2006; 57(Suppl 11): 133-44.

12. Santhanam L. Arginase and vascular aging. J Appl Physiol 2008; 105: 1632-42.

13. Donato AJ, Eskurza I, Silver AE, et al. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endotheliumdependent dilation and upregulation of nuclear factor-kappaB. Circ Res 2007; 100(11): 1659-66.

14. Ezekowitz J, McAlister F, Armstrong P. Anemia Is Common in Heart Failure and Is Associated With Poor Outcomes: Insights From a Cohort of 12 065 Patients With New-Onset Heart Failure. Circulation 2003; 107: 223-5.

15. Wautier JL, Schmidt AM. Protein glycation: a firm link to endothelial cell dysfunction. Circ Res 2004; 95: 233-8.

16. Basak GW, Yasukawa S, Alfaro A, et al. Human embryonic stem cells hemangioblast express HLA-antigens. J Transl Med 2009; 7: 27.

17. Stump MM, Jordan GL Jr, Debakey ME, et al. Endothelium Grown from Circulating Blood on Isolated Intravascular Dacron Hub. Am J Pathol 1963; 43: 361-7.

18. Korbling M, Reuben JM, Gao H, et al. Recombinant human granulocytecolony-stimulating factor-mobilized and apheresis-collected endothelial progenitor cells: a novel blood cell component for therapeutic vasculogenesis. Transfusion 2006; 46: 1795-802.

19. Shintani S, Murohara T, Ikeda H, et al. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation 2001; 103: 2776-9.

20. Werner N, Junk S, Laufs U, et al. Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury. Circ Res 2003; 93: e17-24.

21. Andrassy M, Volz HC, Igwe JC, et al. High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation 2008; 117: 3216-26.

22. Sobrino T, Hurtado O, Moro MA, et al. The increase of circulating endothelial progenitor cells after acute ischemic stroke is associated with good outcome. Stroke 2007; 38: 2759-64.

23. Hatada T, Wada H, Nobori T, et al. Plasma concentrations and importance of High Mobility Group Box protein in the prognosis of organ failure in patients with disseminated intravascular coagulation. Thromb Haemost 2005; 94: 975-9.

24. Hristov M, Zernecke A, Schober A, et al. Adult progenitor cells in vascular remodeling during atherosclerosis. Biol Chem 2008; 389: 837-44.

25. Zhao Q, Ren H, Zhu D, et al. Stem/progenitor cells in liver injury repair and regeneration. Biol Cell 2009; 101: 557-71.

26. Sun Y. Myocardial repair/remodelling following infarction: roles of local factors. Cardiovasc Res 2009; 81: 482-90.

27. Shimada T, Takeshita Y, Murohara T, et al. Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation 2004; 110: 1148-55.

28. Spyridopoulos I, Isner JM, Losordo DW. Oncogenic ras induces premature senescence in endothelial cells: role of p21(Cip1/Waf1). Basic Res Cardiol 2002; 97: 117-24.

29. Kelm M. Flow-mediated dilatation in human circulation: diagnostic and therapeutic aspects. Am J Physiol Heart Circ Physiol 2002; 282: H1-5.

30. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-5.

31. Andrawis N, Jones DS, Abernethy DR. Aging is associated with endothelial dysfunction in the human forearm vasculature. J Am Geriatr Soc 2000; 48: 193-8.

32. Ghiadoni L, Cupisti A, Huang Y, et al. Endothelial dysfunction and oxidative stress in chronic renal failure. J Nephrol 2004; 17: 512-9.

33. Bilsborough W, Keen H, Taylor A, et al. Anti-tumour necrosis factor-alpha therapy over conventional therapy improves endothelial function in adults with rheumatoid arthritis. Rheumatol Int 2006; 26: 1125-31.

34. Hurks R, Eisinger MJ, Goovaerts I, et al. Early endothelial dysfunction in young type 1 diabetics. Eur J Vasc Endovasc Surg 2009; 37: 611-5.

35. Li Z, Froehlich J, Galis ZS, et al. Increased Expression of Matrix Metalloproteinase-2 in the Thickened Intima of Aged Rats. Hypertension 1999; 33: 116-23.

36. Risinger GM, Dawn L. Updike, Bullen EC, et al. TGF- suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB. Am J Physiol 2010; 298: C191-201.

37. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness. Arterioscler Thromb Vasc Biol 2005; 25: 932-43.

38. Konova E, Baydanoff S, Atanasova M, et al. Age-related changes in the glycation of human aortic elastin. Exp Gerontol 2004; 39(2): 249-54.

39. Tilman B. Drueke. Arterial Intima and Media Calcification: Distinct Entities with Different Pathogenesis or All the Same? Clin J Am Soc Nephrol 2008; 3: 1583-4.

40. Blankenhorn DH. Stern D. Calcification of the coronary arteies. Am J Roentgenol Radium the Nucl Med. 1959; 81: 772-7.

41. Persy V, D’Haese P. Vascular calcification and bone disease: the calcification paradox. Trends Mol Med 2009; 15(9): 405-16.

42. Arad Y, Goodman KJ, Roth M, et al. Coronary calcification, coronary disease risk factors, C-reactive protein, and atherosclerotic cardiovascular disease events: the St. Francis Heart Study. JACC 2005; 46(1): 158-65.

43. Budoff MJ, Shaw LJ, Sandy T, et al. Long-Term Prognosis Associated With Coronary Calcification. Observations From a Registry of 25,253 Patients. JАСC 2007; 49: 1860-70.

44. Fuster V, Moreno PR, Fayad ZA, et al. Badimon, Atherothrombosis and High-Risk Plaque: Part I: Evolving Concepts. JACC 2005; 937-54.

45. Elmariah S, Delaney JAC, O’Brien KD, et al. Bisphosphonate Use and Prevalence of Valvular and Vascular Calcification in Women MESA (The Multi-Ethnic Study of Atherosclerosis). JACС 2010; 56: 1752-9.

46. Uzzan B, Cohen R, Nicolas P, et al. Effects of statins on bone mineral density: a meta-analysis of clinical studies. Bone 2007; 40(6): 1581-7.

47. Kuro-o M, Matsumura Y, Aizawa H, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 6: 390(6655): 45-51.

48. Arking DE, Becker DM, Yanek LR, et al. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet 2003; 72(5): 1154-61.

49. Arking DE, Krebsova A, Macek M Sr, et al. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci U S A 2002; 99(2): 856-61.

50. Giachelli CM. Vascular Calcification: In Vitro Evidence for the Role of Inorganic Phosphate. J Am Soc Nephrol 2003; 14: S300-4.

51. Sato K, Urist MR. Induced regeneration of calvaria by bone morphogenetic protein (BMP) in dogs. Clin Orthop Relat Res 1985; 197: 301-11.

52. Demer LL. A Skeleton in the Atherosclerosis Closet. Circulation 1995; 92: 2029-32.

53. Medici D, Shore EM, Lounev VY, et al. Conversion of vascular endothelial cells into multipotent stem-like cells. Nature Medicine 2010; 16: 1400-6.

54. Vlachopoulos C, Aznaouridis K , Stefanadis C. Prediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness. A Systematic Review and Meta-Analysis. JACC 2010; 55: 1318-27.

55. Orlandi A, Marcellini M, Spagnoli LG. Aging influences development and progression of early aortic atherosclerotic lesions in cholesterol-fed rabbits. Arterioscler Thromb Vasc Biol 2000; 20: 1123-36.

56. Fleg JL, O’Connor FC, Gerstenblith G, et al. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol 1995; 78: 890-900.

57. Spinetti G, Wang M, Monticone R, et al. Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler Thromb Vasc Biol 2004;24: 1397-402.

58. Wang M, Lakatta EG. Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging. Hypertension 2002; 39: 865-73.

59. Blacher J, Asmar R, Djane S, et al. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 1999; 33: 1111-7.

60. Laurent S, Cockcroft J, Van Bortel L, et al, for the European Network for Non-invasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27: 2588-605.

61. Mancia G, de Backer G, Cifkova R, et al. Guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Cardiology (ESC) and of the European Society of Hypertension (ESH). J Hypertens 2007; 25: 1105-87.

62. Boutouyrie P, Tropeano AI, Asmar R, et al. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension 2002; 39: 10-5.

63. Cherkas LF, Aviv A, Valdes AM, et al. The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell 2006; 5: 61-5.

64. Adams JM, White M. Biological ageing. A fundamental, biological link between socio-economic status and health? Eur J Pub Health 2004; 14: 331-4.

65. Scuteri A, Najjar SS, Muller DC, et al. Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness. JACC 2004; 43: 1388-95.

66. Balkestein EJ, Aggel-Leijssen DP, van Baak MA, et al. The effect of weight loss with or without exercise training on large artery compliance in healthy obese men. J Hypertens 1999; 17: 1831-5.

67. Avolio AP, Clyde KM, Beard TC, et al. Improved arterial distensibility in normotensive subjects on a low salt diet. Arteriosclerosis 1986; 6: 166-9.

68. McEniery CM, Schmitt M, Qasem A, et al. Nebivolol increases arterial distensibility in vivo. Hypertension 2004; 44: 305-10.

69. Tropeano AI, Boutouyrie P, Pannier B, et al. Brachial pressure-independent reduction in carotid stiffness after long-term angiotensin-converting enzyme inhibition in diabetic hypertensives. Hypertension 2006; 48: 80-6.

70. Karalliedde J, Smith A, DeAngelis L, et al. Valsartan improves arterial stiffness in type 2 diabetes independently of blood pressure lowering. Hypertension 2008; 51: 1617-23.

71. Staessen J, Bulpitt CJ, Fagard R, et al.The influence of menopause on blood pressure. J Hum Hypertens 1989; 3: 427-33.

72. Rajkumar C, Kingwell BA, Cameron JD, et al. Hormonal therapy increases arterial compliance in postmenopausal women. JACC 1997; 30: 350-6.

73. Angerer P, Kothny W, Stork S, et al. Hormone replacement therapy and distensibility of carotid arteries in postmenopausal women: a randomized, controlled trial. JACC 2000; 36: 1789-96.

74. Hodis HN, Mack WJ, Azen SP, et al., for the Women’s Estrogen-Progestin Lipid-Lowering Hormone Atherosclerosis Regression Trial Research Group. Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women. N Engl J Med 2003; 349: 535-45.

75. Teede HJ, Liang YL, Kotsopoulos D, et al. Placebo-controlled trial of transdermal estrogen therapy alone in postmenopausal women: effects on arterial compliance and endothelial function. Climacteric 2002; 5: 160-9.

76. Kanis JA, Burlet N, Cooper C, et al, for the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 2008; 19: 399-428.

77. Kass DA, Shapiro EP, Kawaguchi M, et al. Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation 2001; 104: 1464-70.


Для цитирования:


Стражеско И.Д., Акашева Д.У., Дудинская Е.Н., Ткачева О.Н. Старение сосудов: основные признаки и механизмы. Кардиоваскулярная терапия и профилактика. 2012;11(4):93-100.

For citation:


Strazhesko I.D., Akasheva D.U., Dudinskaya E.N., Tkacheva O.N. Vascular ageing: main symptoms and mechanisms. Cardiovascular Therapy and Prevention. 2012;11(4):93-100. (In Russ.)

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