Preview

Cardiovascular Therapy and Prevention

Advanced search

ASSESSMENT OF RELATIONSHIP FOR GRACE SCORE AND CORONARY LESION SEVERITY IN YOUNG PATIENTS WITH ACUTE CORONARY SYNDROME

https://doi.org/10.15829/1728-8800-2016-3-31-36

Abstract

Aim. The analysis of relationship between coronary arteries lesion, patients’ age, type of acute coronary syndrome (ACS) and risk level by GRACE.

Material and methods. Totally, 179 patients included at the age 24-65 y.o. (mean age 51,2±7,0), hospitalized for ACS. All patients underwent coronary angiography during hospitalization.

Results. In ST elevation ACS two-vessel disease was more common (28,6%), comparing to those with non-ST ACS (15,1%), р=0,031. Regardless the correlation of GRACE risk with age, there was no relation of coronary lesion with age in our study. Mean calculated points by GRACE in non-ST ACS were 95,9±3,3, low risk patients predominated (66,2%). Also, among those with low risk by GRACE, in 48,9% coronary arteriogram showed high risk coronary anatomy.

Conclusion. Low calculated risk by GRACE in young patients has low predicting ability for severe coronary lesion, which is important to note in management of non-ST elevation ACS. 

About the Authors

I. S. Skopets
Petrozavodsk State University. Petrozavodsk
Russian Federation


N. N. Vezikova
Petrozavodsk State University. Petrozavodsk
Russian Federation


References

1. Libby P, et al. Braunwald’s heart disesase: a textbook of cardiovascular medicine. 8th ed. Moscow (Russia): Logosphera: 2010. 624 p. R.G. Oganov, editor, vol.1, Chapters 1-20. Russian (Либби П. и др. Болезни сердца по Браунвальду: руководство по сердечно-сосудистой медицине. 8-е изд. М (Россия): Логосфера: 2010. 624 c. Пер. с англ., под общ.ред. Р.Г. Оганова, том 1, главы 1-20).

2. Shalnova SA, Oganov RG, Steg JF. Ischemic heart disease. Current reality of the World Register CLARIFY. Kardiologiia 2013; 8: 28-33. Russian (Шальнова С.А., Оганов Р.Г. Стэг Й.Ф. Ишемическая болезнь сердца. Современная реальность по данным всемирного регистра CLARIFY. Кардиология 2013; 8: 28-33).

3. Shalnova SA, Conradi AO, Karpov UA, et al. Cardiovascular mortality in 12 Russian Federation regions — participants of the “Cardiovascular Disease Epidemiology in Russian Regions” study. Russ J Cardiol 2012; 5 (97): 6-11. Russian (Шальнова С.А., Конради А.О., Карпов Ю.А. др. Анализ смертности от сердечно-сосудистых заболеваний в 12 регионах Российской Федерации, участвующих в исследовании “Эпидемиология сердечно-сосудистых заболеваний в различных регионах России”. Российский кардиологический журнал 2012; 5 (97): 6-11).

4. Hamm CW, Bassand JP, Agewall S, et al. Guidelines of the European Society of Cardiology for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. European Heart Journal 2011; 32: 29993054.

5. Fox KА, Dabbous OH, Goldberg RJ, et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE) BMJ 2006; 333(7578): 1091.

6. Tang EW, Wong CK, Herbison P. Global Registry of Acute Coronary Events (GRACE) hospital discharge risk score accurately predicts long-term mortality post acute coronary syndrome. Am Heart J 2007; 153(1): 29-35.

7. Beigel R, Matetzky S, Gavrielov-Yusim N, et al. Predictors of high-risk angiographic findings in patients with non-ST-segment elevation acute coronary syndrome. Catheter Cardiovasc Interv 2014; 83(5): 677-83.

8. Barbosa CE, Viana M, Brito M, et al. Accuracy of GRACE and TIMI scores in predicting the angiographic severity of acurte coronary syndrome. Arq Bras Cardiol 2012; 99(3): 818-24.

9. Zykov MV, Barbarash OL, Zykova VN, et al. Comparative characteristics of scales predicting hospital mortality in patients with myocardial infarction. Russ J Cardiol 2012; 1: 11-6. Russian (Зыков М.В., Барбараш О.Л., Зыкова В.Н. др. Сравнительная характеристика шкал прогнозирования госпитальной летальности у больных инфарктом миокарда Российский кардиологический журнал 2012, 1: 11-6).

10. Kim HK, Jeong MH, Ahn Y, et al. Hospital discharge risk score system for the assessment of clinical outcomes in patients with acute myocardial infarction (Korea Acute Myocardial Infarction Registry [KAMIR] score) Am J Cardiol 2011; 107(7): 965-71.

11. Mahmood M, Achakzai AS, Akhtar P, et al. Comparison of the TIMI and the GRACE risk scores with the extent of coronary artery disease in patient with non-ST-elevation acute coronary syndrome. Journal of Pakistan medical association 2013; 83(6): 691-5.

12. Thygesen К, Joseph SA, Allan S, et al. Third universal definition of myocardial infarction. Russ J Cardiol 2013; 2(100), Appendix 1. Russian (Thygesen К, Joseph SA, Allan S. Третье универсальное определение инфаркта миокарда. Российский кардиологический журнал 2013; 2(100). Прил.1).

13. Cakar MA, Sahinkus S, Aydin E, et al. Relation between the GRACE score and severity of atherosclerosis in acute coronary syndrome. J Cardiol 2014; 63(1): 24-8.

14. Golopheevsky VYu, Inozemtsev SA, Sotnikov AV, et al. Myocardial infarction development hazards in young and middle aged patients. Bulletin of St. Petersburg State University 2007; 11(3):3-10. Russian (Голофеевский В.Ю., Иноземцев С.А., Сотников А.В. и др. Факторы риска инфаркта миокарда у пациентов молодого с среднего возраста. Вестник Санкт-Петербургского университета 2007, 11(3): 3-10).

15. Nicolau JC, Moreira HG, Baracioli LM, et al. The bleeding risk score as a mortality predictor in patients with acute coronary syndrome. Arq Bras Cardiol 2013; 101(6): 511-8.

16. Romano ER. Prognostic Score for Acute Coronary Syndrome in a Private Terciary Hospital Arq Bras Cardiol 2014; 102(3): 226-36.


Review

For citations:


Skopets I.S., Vezikova N.N. ASSESSMENT OF RELATIONSHIP FOR GRACE SCORE AND CORONARY LESION SEVERITY IN YOUNG PATIENTS WITH ACUTE CORONARY SYNDROME. Cardiovascular Therapy and Prevention. 2016;15(3):31-36. (In Russ.) https://doi.org/10.15829/1728-8800-2016-3-31-36

Views: 916


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)