Hypertension as a death risk factor in men and women aged 20-59 years: a 34-year cohort prospective study
https://doi.org/10.15829/1728-8800-2023-3602
EDN: DNFNSW
Abstract
Aim. To study the effect of hypertension (HTN) on the risk of cardiovascular and all-cause death among men and women aged 20-59 years among Tomsk population in a 34-year cohort prospective study.
Material and methods. The study was carried out on the model of Tomsk population. At stage I (1988-1991), 1546 people (630 men and 916 women) aged 20-59 years were examined, the prevalence of hypertension among which was studied. At stage II (2022), the effect of HTN on and all-cause death risk was analyzed.
Results. A significant effect of HTN on mortality was revealed: the relative risk (RR) of all-cause and cardiovascular death was 1,9 (p<0,001) and 2,7 (p<0,001), respectively. Among men, HTN increased the risk of all-cause death by 1,4 times (p<0,001); among women — 2,5 times (p<0,001). The RR of cardiovascular death among men with HTN was 1,5 (p<0,05); among women with hypertension — 5,2 (p<0,001). The RR of non-cardiovascular death in HTN persons was 1,4 (p<0,01). Mean blood pressure at primary screening were higher in non-survivors compared to survivors. This pattern was observed in all sex and age groups. Among persons with initially normal blood pressure, the 34-year survival rate was 70,9%, while with increased blood pressure — 45,1%.
Conclusion. The results of a 34-year cohort prospective study confirm the significant impact of HTN on the death risk and survival prognosis.
About the Authors
I. V. Dolgalev
Siberian State Medical University
Russian Federation
Russian Federation
Igor V. Dolgalev, Doctor of Medical Sciences, Head of the Intermediate Level Therapy Division with Clinical Pharmacology Course
Tomsk
A. Yu. Ivanova
Siberian State Medical University
Russian Federation
Russian Federation
Alena Yu. Ivanova, Candidate of Medical Sciences, Associate Professor of the Intermediate Level Therapy Division with Clinical Pharmacology Course
Tomsk
A. Yu. Shipkhineeva
Siberian State Medical University
Russian Federation
Russian Federation
Aleksandra Yu. Shipkhineeva, Assistant of the Intermediate Level Therapy Division with Clinical Pharmacology Course
Tomsk
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Supplementary files
What is already known about the subject?
- Hypertension (HTN) is one of the most common diseases and modifiable risk factors for cardiovascular disease and death.
- The influence of risk factors, including HTN, on the death risk in long-term prospective studies should be assessed.
What might this study add?
- The results of a 34-year cohort prospective study confirm the significant impact of HTN on the death risk.
- HTN increases the all-cause and cardiovascular death risk by 1,9 and 2,7 times, respectively.
- The 34-year survival rate in persons with initially normal blood pressure was 70,9%, with elevated values — 45,1%.
Review
For citations:
Dolgalev I.V., Ivanova A.Yu., Shipkhineeva A.Yu. Hypertension as a death risk factor in men and women aged 20-59 years: a 34-year cohort prospective study. Cardiovascular Therapy and Prevention. 2023;22(8):3602. (In Russ.) https://doi.org/10.15829/1728-8800-2023-3602. EDN: DNFNSW
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