EVALUATION OF THE ROLE OF HYPERHOMOCYSTEINEMIA AND POLYMORPHISM C677T GENE OF METHYLTETRAHYDROFOLATEREDUCTASE IN DEVELOPMENT OF CHRONIC HEART FAILURE

Aim. To study the influence of polymorphism of the gene methyltetrahydrofolate-reductase (MTHFR) — polymorhic locus С677Т, and level of homocysteine  in blood plasma on the risk of development and course of chronic heart failure (CHF).

Material and methods. Totally, 277 persons  studied  with CHF II-IV functional classes (FC NYHA). The polymorphism С677Т of gene MTHFR studied via polymerase chain reaction. With the aim to reveal association of homocysteine  with the course  of CHF patients were selected  by the results  of year-long observation  to 2 groups:  with benign (n=49) and adverse  (n=45) course.  During the period the following was assessed: increase  of  symptoms  and  severity  of  CHF, hospitalizations  rate, dynamics of the left ventricle ejection fraction.

Results. Carriage  of allele T and  genotype  T/T of polymorphic locus С677Т gene MTHFR was associated with more severe clinical picture of CHF. In CHF patients of II-IV FC homocysteine concentration in serum was significantly, 2-3 times, higher comparing to the controls, regardless of age. In adverse course group the level was highest comparing to benign course.

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