Coronary atherosclerosis and delirium in patients with myocardial infarction
V. V. Mazur,
A. N. Orlova,
N. D. Bazhenov,
E. S. Mazur,
R. M. Rabinovich,
T. O. Nikolaeva,
Yu. A. Orlov https://doi.org/10.15829/1728-8800-2025-4450
EDN: MJYQNE
Abstract
Aim. To compare clinical characteristics and severity of coronary atherosclerosis in patients with myocardial infarction (MI) with and without delirium.
Material and methods. The registry of 2537 patients with MI hospitalized in 2023 in the Tver Regional Clinical Hospital was analyzed. Delirium was diagnosed in 58 patients (2,3%) who were included in group 1, and 2479 patients without delirium from group 2. The Gensini score was calculated in 53 patients with delirium (main group) and 106 patients without delirium, included in the comparison group by selecting age-matched pairs.
Results. Patients in group 1 were on average older than patients in group 2 (76,0 vs 66,0 years, p<0,001), they had a lower left ventricular ejection fraction (43,0 vs 46,0%, p<0,001), more often developed stroke during hospitalization (8,6 vs 1,4%, p<0,001) and death (17,2 vs 6,4%, p=0,001). The main and control groups were comparable in all variables taken into account, with the exception of Gensini score. Mean Gensini score was higher in the main group than in the control group — 64,0 vs 46,0 (p=0,002).
Conclusion. Delirium in MI develops mainly in people >69 years old with an ejection fraction <45%. Coronary atherosclerosis in patients with MI with delirium is, on average, more pronounced than in patients without mental disorders.
About the Authors
V. V. Mazur
Tver State Medical University,
Russian Federation
Russian Federation
Vera V. Mazur — MD, Chair of Hospital Therapy and Occupational Diseases
Tver
A. N. Orlova
Tver State Medical University,
Russian Federation
Russian Federation
Anna N. Orlova — Chair of Emergency Medical Care
Tver
N. D. Bazhenov
Tver State Medical University,
Russian Federation
Russian Federation
Nikolay D. Bazhenov — MD, Head of Chair of Emergency Medical Care
Tver
E. S. Mazur
Tver State Medical University,
Russian Federation
Russian Federation
Evgeniy S. Mazur — MD, Professor, Head of Chair of Hospital Therapy and Occupational Diseases
Tver
R. M. Rabinovich
Tver State Medical University;
Regional Clinical Hospital
Russian Federation
Russian Federation
Tver
T. O. Nikolaeva
Tver State Medical University
Russian Federation
Russian Federation
Tat’yana O. Nikolaeva — PhD, Head of Chair of internal diseases
Tver
Yu. A. Orlov
ФГБОУ ВО "Тверской государственный медицинский университет" Минздрава России
Russian Federation
Russian Federation
Yuriy A. Orlov — Ph.D., Docent of the Department of Hospital Therapy
Tver
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For citations:
Mazur V.V., Orlova A.N., Bazhenov N.D., Mazur E.S., Rabinovich R.M., Nikolaeva T.O., Orlov Yu.A. Coronary atherosclerosis and delirium in patients with myocardial infarction. Cardiovascular Therapy and Prevention. 2025;24(8):4450. (In Russ.) https://doi.org/10.15829/1728-8800-2025-4450. EDN: MJYQNE
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