ADIPOQ rs266729/rs182052 haplotypes and the risk of coronary artery disease

Aim. To validate previous findings on the association of the rs266729 and rs182052 single nucleotide polymorphisms (SNPs) of the ADIPOQ gene with the risk of coronary artery disease (CAD) using an independent sample.

Material and methods. The study included a sub-cohort of patients (n=874) from the Vologda, Omsk, Krasnoyarsk and Primorsky Regions of the ESSE-RF population study and a sample of patients (n=258) from the biobank collection of the National Medical Research Center for Therapy and Preventive Medicine.

Results. We revealed significant association of the alternative C allele of the rs266729 SNP in a recessive univariate model with an increased risk of CAD (odds ratio (OR)=2,008, p=0,014). Based on the analysis of the rs266729 and rs182052 SNPs, four following haplotypes were identified: CG (48,2%), GA (29,0%), CA (12,6%), and GG (10,2%). Associations of the GA haplotype (OR=2,086, p=0,010) and CA haplotype (OR=4,160, p=0,032) with CAD were demonstrated in a recessive multivariate model.

Conclusion. The GA and CA haplotypes of the ADIPOQ rs266729/ rs182052 SNPs are associated with CAD and can be used to assess the CAD risk in Russian population.

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