Missing and incorrect data in clinical trials: impact on the final result and ways of prevention
https://doi.org/10.15829/1728-8800-2025-4572
EDN: QIGEJM
Abstract
This article presents information on missing and incorrect data in clinical trials in medicine and their impact on the results It describes the significance of lost to follow-up patients in prospective studies and individual missing data for a specific patient. An example of a database of the acute coronary syndrome (ACS) registry with missing data is given. The article also mentions the issue of fake data. It discusses various methods for filling in missing data in clinical registries and the main principles for preventing them. The article analyzes Russian ACS registris in terms of missing data and patients lost to follow-up.
About the Author
S. Yu. Martsevich
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
Petroverigsky Lane, 10, bld. 3, Moscow, 101990
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Supplementary files
What is already known about the subject?
- Clinical trials often contain missing and incorrect data, which, if ignored, can lead to incorrect conclusions.
What might this study add?
- A specific example of a table with missing data from an acute coronary syndrome registry is provided. Russian acute coronary syndrome registries are analyzed for missing data and patients lost to follow-up.
Review
For citations:
Martsevich S.Yu. Missing and incorrect data in clinical trials: impact on the final result and ways of prevention. Cardiovascular Therapy and Prevention. 2025;24(10):4572. (In Russ.) https://doi.org/10.15829/1728-8800-2025-4572. EDN: QIGEJM
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