Новые возможности в лечении ишемической болезни сердца
Аннотация
Статья посвящена проблеме применения ингибиторов ангиотензин-превращающего фермента (иАПФ) при лечении стабильных форм ишемической болезни сердца (ИБС). Она содержит сведения о результатах, полученных в многоцентровых исследованиях, посвященных эффективности различных иАПФ для снижения риска общей смертности, вероятности развития фатального и нефатального инфаркта миокарда, мозгового инсульта, хронической сердечной недостаточности у больных ИБС.
Эффективность иАПФ при ИБС связывают с влиянием препарата на эндотелиальную дисфункцию, факторы тромбоза и воспаления, увеличение продукции брадикинина, повышение активности NO-синтетазы. Недавно завершенное исследование EUROPA продемонстрировало, что периндоприл в дозе 8 мг/сут может быть рекомендован больным для терапии стабильной формы ИБС.
Об авторе
В. И. МаколкинРоссия
Тел.: (095) 248-77-15
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Рецензия
Для цитирования:
Маколкин В.И. Новые возможности в лечении ишемической болезни сердца. Кардиоваскулярная терапия и профилактика. 2005;4(1):90-95.
For citation:
Makolkin V.I. New perspectives in coronary heart disease management. Cardiovascular Therapy and Prevention. 2005;4(1):90-95. (In Russ.)