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Кардиоваскулярная терапия и профилактика

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Растительные стерины и станолы как пищевые факторы, снижающие гиперхолестеринемию путем ингибирования всасывания холестерина в кишечнике

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Аннотация

Обзор посвящен механизму действия, гиполипидемической активности, структурной характеристике и безопасности применения растительных стеринов и станолов. Фитостерины и фитостанолы ингибируют всасывание холестерина (ХС) в кишечнике, тем самым снижают его уровень в плазме крови. Особое внимание уделено проспективным эпидемиологическим исследованиям, в которых на репрезентативной выборке показано, что концентрация фитостеринов и фитостанолов в плазме крови у пациентов с ишемической болезнью сердца (ИБС) была значительно ниже по сравнению с лицами без этого заболевания. При оценке относительного риска было обнаружено, что двукратное увеличение концентрации ситостерина в сыворотке крови связано со снижением риска ИБС на 22 %. Показано, что эфиры растительных стеринов и станолов могут рассматриваться как эффективные и безопасные ингредиенты, обогащение пищи которыми снижает уровень ХС в крови — одного из основных факторов риска сердечнососудистых заболеваний.

Об авторах

М. А. Хучиева
ФГУ Государственный научно-исследовательский центр профилактической медицины Минздравсоцразвития России
Россия

м.н.с. отдела вторичной профилактики ХНИЗ

Москва, Тел.: (915) 209-33-10






Н. В. Перова
ФГУ Государственный научно-исследовательский центр профилактической медицины Минздравсоцразвития России
Россия

в.н.с. отдела изучения биохимических маркеров риска ХНИЗ

Москва



Н. М. Ахмеджанов
ФГУ Государственный научно-исследовательский центр профилактической медицины Минздравсоцразвития России
Россия

в.н.с. отдела вторичной профилактики ХНИЗ

Москва



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Для цитирования:


Хучиева М.А., Перова Н.В., Ахмеджанов Н.М. Растительные стерины и станолы как пищевые факторы, снижающие гиперхолестеринемию путем ингибирования всасывания холестерина в кишечнике. Кардиоваскулярная терапия и профилактика. 2011;10(6):124-132.

For citation:


Khuchieva M.A., Perova N.V., Akhmedzhanov N.M. Plant sterols and stanols as dietary factors reducing hypercholesterolemia by inhibiting intestinal cholesterol absorption. Cardiovascular Therapy and Prevention. 2011;10(6):124-132. (In Russ.)

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