Breast artery calcification and osteoporosis in postmenopausal woman: a case report and opinion on the problem
https://doi.org/10.15829/1728-8800-2020-2574
Abstract
Mammography is one of the most common screening test in the female population. In addition to identifying breast cancer, vascular calcification is clearly visualized on the mammogram, which is associated with an increased risk of cardiovascular disease, atherosclerosis, and a number of other chronic non-communicable diseases. The article presents a case report of a postmenopausal woman with breast artery calcification and osteoporosis. Identification of women at risk of non-cancer diseases significantly expands the prospects of using mammography for screening.
About the Authors
E. V. Bochkareva
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Elena V. Bochkareva, MD, Ph.D., Head of Laboratory of Drug Prevention in the Primary Care, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Healthcare System,
Russian Federation
Elena V. Bochkareva, MD, Ph.D., Head of Laboratory of Drug Prevention in the Primary Care, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Healthcare System,
E. K. Butina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
MD, Ph.D., Senior Researcher, Laboratory of Drug Prevention in the Primary Care, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Healthcare System,
Russian Federation
MD, Ph.D., Senior Researcher, Laboratory of Drug Prevention in the Primary Care, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Healthcare System,
A. S. Savin
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
Postgraduate, Laboratory of Drug Prevention in the Primary Care, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Healthcare Systemw
O. M. Drapkina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
MD, PhD, Professor, Corresponding Member of the Russian Academy of Sciences, Director,
Russian Federation
MD, PhD, Professor, Corresponding Member of the Russian Academy of Sciences, Director,
References
1. Lai KC, Slanetz PJ, Eisenberg RL. Linear breast calcifications. Am J Roentgenol. 2012;199:W151-7. doi:10.2214/AJR.11.7153.
2. Bochkareva EV, Kim IV, Butina EK, et al. Mammographic Screening as a Tool for Cardiovascular Risk Assessing. Part 1. Breast Arterial Calcification: Pathomorphology, Prevalence and Risk Factors. Rational Pharmacotherapy in Cardiology. 2019;15(2):244-250. (In Russ.). doi:10.20996/1819-6446-2019-15-2-244-250.
3. Bochkareva EV, Kim IV, Butina EK, et al. Mammographic Screening as a Tool for Cardiovascular Risk Assessing. Part 2. ssociation of Breast Arterial Calcification and Cardiovascular Diseases. Rational Pharmacotherapy in Cardiology. 2019;15(3):424-30. (In Russ.). doi:10.20996/1819-6446-2019-15-3-424-430.
4. Reddy J, Bilezikian JP, Smith SJ, Mosca L. Reduced bone mineral density is associated with breast arterial calcification. J Clin Endocrinol Metab. 2008;93(1):208-11. doi:10.1210/jc.2007-0693.
5. Atci N, Elverici E, Kurt RK, et al. Association of breast arterial calcification and osteoporosis in Turkish women. Pak J Med Sci. 2015;31(2):444-7. doi:10.12669/pjms.312.6120.
6. Margolies L, Salvatore M, Hecht HS, et al. Digital Mammography and Screening for Coronary Artery Disease. JACC Cardiovasc Imaging. 2016;9:350-60. doi:10.1016/j.jcmg.2015.10.022.
7. Yoon YE, Kim KM, Han JS, et al. Prediction of Subclinical Coronary Artery Disease With Breast Arterial Calcification and Low Bone Mass in Asymptomatic Women Registry for the Women Health Cohort for Breast, Bone, and Coronary Artery Disease Study. JACC Cardiovasc Imaging. 2019;12(7 Pt 1):1202-11. doi:10.1016/j.jcmg.2018.07.004.
8. Dale PS, Mascarenhas CR, Richards M, Mackie G. Mammography as a Screening Tool for Diabetes. J Surg Res. 2010;159:528-31. doi:10.1016/j.jss.2008.11.837.
9. Farhat GN, Cauley JA, Matthews KA, et al. Volumetric BMD and vascular calcification in middle-aged women: the Study of Women’s Health Across the Nation. J Bone Miner Res. 2006;21:1839-46. doi:10.1359/jbmr.060903.
10. Kiel DP, Kauppila LI, Cupples LA, et al. Bone Loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int. 2001;68(5):271-6. doi:10.1007/bf02390833.
11. Hak AE, Pols HA, van Hemert AM, et al. Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study. Arterioscler Thromb Vasc Biol. 2000;20(8):1926-31. doi:10.1161/01.atv.20.8.1926.
12. Schulz E, Arfai K, Liu X, et al. Aortic calcification and the risk of osteoporosis and fractures. J Clin Endocrinol Metab. 2004;89:4246-53. doi:10.1210/jc.2003-030964.
13. Zhang Y, Feng B. Systematic review and meta-analysis for the association of bone mineral density and osteoporosis/osteopenia with vascular calcification in women. Int J Rheum Dis. 2017;20:15460. doi:10.1111/1756-185X.12842.
14. Lampropoulos CE, Kalamara P, Konsta M, et al. Osteoporosis and vascular calcification in postmenopausal women: a crosssectional study. Climacteric. 2016;19(3):303-7. doi:10.3109/1369-7137.2016.1164134.
15. Bagger YZ, Tankó LB, Alexandersen P, et al. Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip. J Intern Med. 2006;259(6):598-605. doi:10.1111/j.1365-2796.2006.01640.x.
16. Hyder JA, Allison MA, Wong N, et al. Association of coronary artery and aortic calcium with lumbar bone density: the MESA Abdominal Aortic Calcium Study. Am J Epidemiol. 2009;169(2):186-94. doi:10.1093/aje/kwn303.
17. Värri M, Tuomainen TP, Honkanen R, et al. Carotid intima-media thickness and calcification in relation to bone mineral density in postmenopausal women-the OSTPRE-BBA study. Maturitas. 2014;78(4):304-9. doi:10.1016/j.maturitas.2014.05.017.
18. Simon SP, Fodor D, Muntean L, et al. Bone mineral density, vertebral fractures and body mass index in postmenopausal women with abdominal aortic calcification. Endocr Res. 2014;39(1):1-6. doi:10.3109/07435800.2013.794425.
19. Caffarelli C, Montagnani A, Nuti R, et al. Bisphosphonates, atherosclerosis and vascular calcification: update and systematic review of clinical studies. Clin Interv Aging. 2017;12:1819-28. doi:10.2147/CIA.S138002.
20. Lampropoulos CE, Papaioannou I, D’Cruz DP. Osteoporosis-a risk factor for cardiovascular disease? Nat Rev Rheumatol. 2012;8(10):587-98. doi:10.1038/nrrheum.2012.120.
21. Hofbauer LC, Brueck CC, Shanahan CM, et al. Vascular calcification and osteoporosis — from clinical observation towards molecular understanding. Osteoporos Int. 2007;18:251-9. doi:10.1007/s00198-006-0282-z.
22. Benevolenskaja LI. Rukovodstvo po osteoporozu. M; BINOM, 2003. р.523. (In Russ.) ISBN: 5-94774-056-7.
23. Price PA, June HH, Buckley JR, Williamson MK. Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D. Arterioscler Thromb Vasc Biol. 2001;21(10):1610-6. doi:10.1161/hq1001.097102.
24. Adibi A, Rabani F, Hovsepian S. Bone density in postmenopausal women with or without breast arterial calcification. Adv Biomed Res. 2017;6:36. doi:10.4103/2277-9175.203161.
25. Iribarren C, Chandra M, Molloi S, et al. No Association between Bone Mineral Density and Breast Arterial Calcification Among Postmenopausal Women. J Endocr Soc. 2019;4(2):bvz026. doi:10.1210/jendso/bvz026.
26. Lesnyak OM, Baranova IA, Belova KYu, et al. Osteoporosis In Russian Federation: Epidemiology, Socio-Medical and Economical Aspects (Review). Traumatology and orthopedics of Russia. 2018;24(1):155-68. (In Russ.). doi:10.21823/2311-2905-2018-241-155-168.
Review
For citations:
Bochkareva E.V., Butina E.K., Savin A.S., Drapkina O.M. Breast artery calcification and osteoporosis in postmenopausal woman: a case report and opinion on the problem. Cardiovascular Therapy and Prevention. 2020;19(4):2574. (In Russ.) https://doi.org/10.15829/1728-8800-2020-2574
Views:
764
Email this article 
